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Since ferroptosis was initially documented more than ten years ago, 11 accumulating data suggests that it is involved in a variety of biological processes, including tumor growth, immune escape, neuron loss, muscle atrophy, and ischemia-reperfusion

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Recent studies have also shown that SAM can act as a therapeutic agent for treating depression, as an antidepressant in Parkinsons disease, and in endogenous and bipolar patients with depression and hypomanic symptoms (67)