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Most GLP-1s* are taken by subcutaneous injection, including the two that are approved by the FDA to treat obesity: Wegovy and Saxenda

For a description of the statutory authority for and existing policies pertaining to the cost performance category, we refer readers to 414.1350 and 414.1380(b)(2) and the CY 2017 Quality Payment Program final rule (81 FR 77162 through 77177), CY 2018 Quality Payment Program final rule (82 FR 53641 through 53648), CY 2019 PFS final rule (83 FR 59765 through 59776), CY 2020 PFS final rule (84 FR 62959 through 62979), CY 2021 PFS final rule (85 FR 84877 through 84881), CY 2022 PFS final rule (86 FR 65445 through 65461), CY 2023 PFS final rule (87 FR 70055 through 70057), CY 2024 PFS final rule (88 FR 79339 through 79349), and CY 2025 PFS final rule (89 FR 98390 through 98408)

It slows gastric emptying, reduces hunger, and improves how the body processes glucose

Sub-chronic Weight Loss in Rats The ability of NN1213 to reduce body weight was tested in DIO rats fed an HFD