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On day 5, mice were given a bottle containing 0.15% saccharin in water for 2 h

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Patients should be advised to report any worsening of digestive symptoms promptly, and dose titration may need to be slower than standard protocols to optimise tolerance

In both single- and multiple-dose studies in healthy subjects, once daily 1,000 mg (2 x 500 mg tablets) dosing provides equivalent systemic exposure, as measured by AUC, and up to 35% higher Cmax of metformin relative to the immediate-release given as 500 mg twice daily