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As more data becomes available, these innovations may shift treatment initiation earlier, with a stronger emphasis on weight and cardiovascular outcomes alongside glucose control

Prescribing considerations: These medications require specialist initiation or shared care arrangements in many NHS settings

The evolution from single to triple agonism The trajectory of incretin-based obesity pharmacotherapy shows a clear pattern of increasing complexity and efficacy: First generation (single agonist): Liraglutide (Saxenda) and semaglutide (Wegovy) target GLP-1 only

2012 2012, April: 4th Annual Best Buddies Banquet, keynote presenter