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Description

The 19S regulatory particle recognizes ubiquitinated proteins and then deubiquitinates, unfolds, and translocates the substrate proteins to the catalytic 20S core, where enzyme-catalyzed cleavage of the substrate protein to its peptides and amino acids takes place

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Our recent study found that NADPH promotes recruitment of ferroptosis suppressor protein 1 (FSP1) to the plasma membrane through N-myristoyltransferase 2 (NMT2), which plays a vital role in resisting KA-mediated neuronal ferroptosis

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