The underlying reason for this toxicity is most likely because neuronal development and survival is based on BCL-XL activity (66)
Estrogen further amplifies hepatic lipogenic capacity and induces the synthesis of yolk precursor lipoproteins, including yolk-targeted very-low-density lipoprotein (VLDLy) and vitellogenin (VTG), thereby synchronizing -3 PUFA metabolism with the reproductive cycle
doi:10.1002/jbt.21432 Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function