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To shed light on the interactions of the enzyme with the natural substrates, we docked flavan-3,3,4-triol ( 4 ) and flavan-3-on-4-ol ( 7 ) into the active pocket of the crystal structure of Pt GSTF8 obtained with ()-catechin ( 12 ) (Extended Data Fig

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A notable limitation of these agents is the need for continuous treatment, as discontinuation has been associated with rebound weight gain (56)

Gold compounds may inhibit selenoproteins by targeting the Sec residue, and mammalian TrxR is a selenoprotein that is especially sensitive to such inhibition [29]