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These include: Pancreatitis (Inflammation of the Pancreas) Gallbladder Disease & Gallstones Kidney Function Changes Metabolic Effects (e.g., Low Blood Sugar) Rare & Emerging Safety Signals Although rare, ongoing safety monitoring continues to identify possible associations and warrant caution: Rare events underscore why medical supervision and regular monitoring are crucial during treatment

Avoid excessive sodium intake, which increases calcium excretion in urine

SLC25A32 is the mitochondrial carrier for the tetrahydrofolate (THF) species in mitochondrial one-carbon (1 C) metabolism, as demonstrated by in vitro studies 23 , mouse genetics 24 and cell culture characterization 25,26,27

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