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This is consistent with the known role of GLP-1R [49,60] and GIPR [37,38] agonism to reduce food intake, primarily but not exclusively via CNS mediated signaling events, and GcgR agonism to induce energy expenditure [54] through mechanisms that are not fully described

This can be caused by various conditions, including gallstones, liver disease, or pancreatic cancer

Phase 2 Benchmarks: Setting the Stage Phase 2 results published in the New England Journal of Medicine and The Lancet provided the first robust evidence of retatrutides potential