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By helping transport fatty acids into the mitochondria, the body can use fat more efficiently as an energy source during physical activity

Moreover, excess leptin activates pro-inflammatory signaling pathways in WAT and immune cells, promoting local and systemic low-grade inflammation and further impairing insulin action [84]

Species differences in peptide metabolism, receptor density, and clearance pathways mean that a compound safe in rats could, in theory, produce unexpected toxicity in humans

184 Finally, many phytochemicals exert anti-nociceptive effects by modulating sensory neuron activity and inflammatory pain pathways