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First, we demonstrated potent inhibition of secretion of gonadotropin, a sex steroid in mice, rats, men, and women by LH-RH antagonists Ac-d-Nal(2)1, d-Phe(4Cl)2, d-Pal(3)3, d-Cit6, d-Ala10-LH-RH (SB-75, cetrorelix) 39