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Nausea, vomiting, and diarrhea were typically the most common gastrointestinal adverse events, occurring in up to 48.4%, 23.2%, and 23.1% of participants, respectively, with events occurring predominantly during dose escalation and decreasing over time [10, 37, 43, 45,46,47]

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The receptors were observed to be located within structures influencing feeding behavior, like the hypothalamus, brainstem, and circumventricular organs like the median eminence and area postrema [45]

That is cross-trial inference, and it cannot establish superiority: the near-identical headline figures are a coincidence of separate experiments, not the result of a race