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in tandem with other human factors such as the human leukocyte antigen (HLA), epigenetics, preexisting comorbidities (i.e., T2DM, CVD, obesity), age, preceding systemic impairments (i.e., hyperinflammation, micro-thrombosis, fibrosis, dysbiosis, autoimmunity, etc.), and socio-demographic factors (i.e., food security, environment, access to medical care) 22,27,28

What Are They & How Do They Work

Comprehensive risk factor management, including glucose control, blood pressure optimization, and lifestyle modification, remains the most effective strategy

Systematic reviews have revealed that GLP-1RAs exert bidirectional modulatory effects on cancer risk, with outcomes varying depending on cancer type, patient characteristics, and study methodology