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It modulates the K + /Na + balance by decreased K efflux and increased expression levels of the inward-rectifying potassium channel ( HvAKT1 ), thereby enhancing salt tolerance by maintaining ionic homeostasis [33]

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Similarly, using cardiac magnetic resonance imaging, the Myocardial-Iron trial demonstrated that intravenous iron administration leads to significant short-term T2* changes, which were also related to improvements in the EF.45 To date, most studies showing iron deficiency in HF and evaluating the effectiveness of various treatments have focused on HFrEF patients

2.4 Immunomodulatory and anti-inflammatory effects GLP-1 receptor agonists have substantial immunomodulatory effects that beyond basic metabolic control