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Tirzepatide achieves reductions of up to 2.0 to 2.3 percentage points, which is among the largest A1c improvements seen with any diabetes medication

However, due to its extended half-life, CJC-1295 provides a more prolonged and stable GH release, leading to consistent levels of IGF-1 without the need for daily administration

Over a 48-week trial in adults with obesity but no diabetes, the highest tested dose of 12 mg once weekly produced an average 24.2% reduction in body weight , compared with just over 2% in the placebo group

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