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The NUD cohort included 21,160 cases and 21,160 controls (n=42,320)

The average density of GABAA receptors in the granular upper and lower layers of the anterior cingulate cortex (ACC), as well as the density of benzodiazepine binding sites in the granular upper and lower layers, was significantly reduced (125)

Detailed Category Analysis# Receptor Targets# Retatrutide : Triple agonist: GIP, GLP-1, and glucagon receptors simultaneously Tirzepatide : Dual agonist: GIP and GLP-1 receptors Advantage : Retatrutide Weight Loss Efficacy# Retatrutide : Up to 28.7% body weight reduction at 68 weeks (Phase 3 TRIUMPH-4)

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