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The expression of HDAC1 is upregulated, and the expression of dual-specificity phosphatase 1 (DUSP1) is downregulated in the unilateral ureteral obstruction (UUO)-induced renal fibrosis mouse model and HK-2 cells treated with TGF-

Indeed, other conditions that slow intracellular metabolism, such as inhibition of mTOR signaling or deprivation of certain amino acids, also appear to increase resistance to ferroptosis through GSH-conserving mechanisms that may be unrelated to nucleotide synthesis (Conlon et al, 2021)

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