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Although its not fully understood, several factors appear to be at play: 1

estimated free phenytoin level (from the total level) estimated free phenytoin level (from the total level) The most accurate equation to estimate the free phenytoin in critically ill patients appears to be the Barra equation: (32049893) Estimated Free phenytoin = 1.69 +0.139(Total phenytoin in mcg/ml) -0.008(Age) -0.424(Albumin in g/dL) +0.01(BUN in mg/dL) +0.288 [Critically Ill (yes, 1

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