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European Journal of Applied Physiology, 121 (12), 3283

Cochrane Database of Systematic Reviews (2019) 3

IV: Understanding the Pharmacokinetic Difference Subcutaneous (SubQ) delivery does have one real advantage over oral dosing: it bypasses first-pass hepatic metabolism, meaning the liver does not immediately degrade what you inject before it enters systemic circulation

INTRODUCTION Vitamin B12 is essential for DNA synthesis, red blood cell formation, and neurologic function[] and is also involved in the metabolism of fat and carbohydrate.[] The clinical manifestations of vitamin B12 deficiency are the effects of depletion on multiple systems, and their severity varies greatly