The authors compared breast cancer incidence among 15,264 women with prior GLP-1 exposure 1 to the same number of women without exposure, with matching for age, BMI, breast density, race, ethnicity, and history of diabetes
In therapeutic settings, specific peptides are administered to target particular functions within the body, helping to restore balance, enhance performance, and promote overall health
Accumulation of senescent cells is responsible for tissue changes leading to aging-related diseases [97,98]
However, the core downstream target genes mediating Nrf2-regulated DR iron metabolism and lipid peroxidation lack in-depth validation, and the optimal activation strategy, long-term safety of Nrf2 pathway and its crosstalk with other ferroptosis regulatory pathways remain insufficiently studied, warranting further investigation