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Editors Note: This article also appeared in the January/February 2026 issue of Consumer Reports magazine.

Saukkonen T, Amin R, Williams RM, Fox C, Yuen KC, White MA, Umpleby AM, Acerini CL, Dunger DB

Cagrilintide side effects Most common (GI-focused): Why GI effects are prominent: Very strong gastric emptying delay Stomach stays full longer Slowed GI transit overall Adaptation occurs over weeks Management strategies: Small frequent meals (5-6 daily) Avoid fatty/greasy foods Ginger supplementation Prescription anti-nausea (Zofran) Fiber and hydration for constipation Protein shakes if can't eat solid food Serious but rare: Pancreatitis ( 20% weight loss (approaching surgery) Side effects higher but manageable Most participants tolerated full doses See our cagrilintide and semaglutide combination guide and cagrisema dosing protocols

The only fully legal route to Lilly-manufactured retatrutide is a clinical trial