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According to NICE Clinical Knowledge Summaries, the health consequences of untreated B12 deficiencyincluding irreversible neurological damage, megaloblastic anaemia, and cognitive impairmentfar outweigh the inconvenience of manageable acne

If your B12 levels are already solid, the impact might be minimal

The studies demonstrated body composition improvements without effects on serum IGF-1 levels, carbohydrate metabolism, or insulin sensitivity

While not every person benefits, and while nausea often resolves on its own after 2-3 weeks on a stable dose, any intervention that improves tolerability increases the likelihood that users remain on treatment long enough to achieve meaningful results