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J Pharmacol Exper Therapeut

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Contact your GP if you experience: Headaches that dont respond to over-the-counter painkillers Headaches lasting more than three days continuously A significant change in headache pattern or a new type of headache Headaches that worsen when lying down, coughing, or straining Headaches accompanied by persistent vomiting that prevents you from staying hydrated Feelings of anxiety or low mood related to your symptoms Seek urgent medical attention (call 999 or go to A&E) if you experience: A sudden, severe headache that reaches maximum intensity within minutes Confusion, drowsiness, or difficulty speaking Visual disturbances (blurring, double vision, or loss of vision) Weakness or numbness, especially on one side of the body A headache with fever and stiff neck These warning signs are not specific to Wegovy but apply to any new or severe headache

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event