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In some individuals, this drop may lead to the return of hunger signals, changes in satiety, or fluctuations in metabolic markers

Additionally, genetic variants in the phosphodiesterase 8B ( PDE8B ) gene, which encodes a high-affinity cAMP-specific phosphodiesterase, as genetic modulators of TSH levels (30, 31), and in the TSH receptor (32) may also influence the setpoint of the HPT axis, potentially contributing to diminished cellular responsiveness to circulating thyroid hormones

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During active treatment, your appetite for certain foods naturally decreases, but this shift is temporary and reverses within weeks to months of discontinuing the medication