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Summary of the AOP Events: Molecular Initiating Events (MIE) Key Events (KE) Adverse Outcomes (AO) Relationships Between Two Key Events (Including MIEs and AOs) Network View Prototypical Stressors Life Stage Applicability Taxonomic Applicability Sex Applicability Overall Assessment of the AOP Biological plausibility, empirical support and quantitative understanding of the KERs and the evidence that uphold essentialities of KEs in this AOP were analyzed together for the overall assessment of an AOP

The monotherapy group had a difference in HbA1c % from baseline of 0.14% vs -0.9% in the combination group ( p = 0.007)

Therefore, although current data support Nrf2 as an important regulatory point upstream of GPX4, its precise mode of action at various stages of OA progression and the long-term safety of pharmacological activation require further systematic investigation

Accessed 26 Apr 2019