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Eur J Drug Metab Pharmacokinet 1995

Strong dual inducers (rifampin, carbamazepine, phenytoin) decrease apixaban exposure by approximately 54% and should be avoided [1]

2.3 Importance of including control and negative reference compounds A key aspect in drug-toxicity evaluation by in vitro metabolomics is the importance of including data from both non-hepatotoxic compounds as well as non-treated cells ( in vitro metabolomics studies, for instance, are often overlooked but can be a significant source of bias in the data, sometimes even more intense than the effects of the drug being tested

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