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The SELECT trial randomized 17,604 people with cardiovascular disease and overweight or obesity, but without diabetes, and followed them for a mean of nearly 40 months

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1 (736) amide infused at near-physiological insulinotropic hormone and glucose concentrations J Clin Endocrinol Metab 1993 76 (4): 912917

8 Therefore, given the increasing burden of lean MASLD in some populations and the benefits of GLP-1RA in weight management, more clinical attention is warranted

In essence, GLP-1 agonist medications work by mimicking the actions of your bodys GLP-1 hormone