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A systematic review and network meta-analysis of 483 full-text articles compared GLP-1RAs and placebo for weight loss

Each medication offers unique benefits and works through distinct mechanisms of action to help our patients achieve better glucose control, appetite regulation, and significant weight loss

Recently, Varin et al., reported that sitagliptin mediated gut-specific and systemic inhibition of DPP-4 improved lipid tolerance and TG production in young mice while these effects were not reproduced in old mice [53]

Additionally, no alternative medications to semaglutide will be discussed, as this article is centered on understanding semaglutide and topiramate