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GLP1 prevented increases in the atrial effective refractory period, P-wave duration, atrial conduction time, atrial conduction velocities and action potential duration, which were observed in dB/dB mice

Overall, the extent to which GLP-1RAs cross the bloodbrain barrier remains uncertain in pre-clinical studies 4 , and further discrepancies are expected in translating these data from animals to humans

Studies examining receptor dynamics have shown that the degree of desensitization varies among tissue types and may be influenced by dose and duration of exposure

Protects cell DNA from damage and inhibits the degradation of collagen fibers