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Treatment of pernicious anemia generally requires intramuscular injections of vitamin B 12 to bypass intestinal absorption

However, development of CAR-T cells or vaccine therapy as senolityc treatment remain, for the moment, difficult because the permanent activation of these therapies could lead to several side effects and potentially eradicate positive activity of senescence

Due to the global opioid crisis, the judicious use of chronic opioids is advised and only after informed decision-making with the patients and with periodic follow-ups to assess efficacy, adverse side effects, compliance, and potential of abuse or misuse

Dominik Malekinusic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia