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Although the role of melatonin in the biosynthesis of essential oil in medicinal plants has not been well understood, one of the mechanisms proposed is related to the similarity in plant function and chemical structure between indole-3-acetic acid (IAA) and melatonin 20,24,28 , which are both derived from chorismate 28

Furthermore, FTO knockdown suppressed the activation of TNF--induced cGAS-STING signaling, accompanied by the decreased expression of inflammatory cytokines such as IL-6 and IL-18, subsequently alleviating AIA (61)

Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H (2008) Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study

Both are preventable