Overall, industrial L-carnitine procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of diabetes, cardiovascular, and kidney disorders, the aging population, its ability to be utilized as a supplement for athletes, its wide range of medical applications, and its usage in oncology
The final mitochondrial step involves the insertion of ferrous iron into the protoporphyrin ring to form the heme group by ferrochelatase (FECH) 31
Screening for this could consist of genetic testing for RET gene mutations, as well as periodic monitoring of the MTC biomarker, calcitonin, found on a full blood count panel
ACKNOWLEDGMENTS This work was supported by the Young Investigator Award 2011 from the Korean Diabetes Association and the Korea Science and Engineering Foundation by the Ministry of Education, Science and Technology (S-2010-1115-000) to Won-Young Lee