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The constrained geometry imposed by the -methyl group ensures that the isobutyl side chain of the leucine moiety is continuously projected into the correct spatial vector, allowing it to interact with the hydrophobic traps of both the GCGR and the GIPR without requiring significant conformational rearrangement or energy expenditure upon binding

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Retrieved from Gao, R., Tao, Y., Zhou, C., et al

Make sure to tell your healthcare provider if you have or have previously had any of the following: Take a certain kind of antidepressant medication called an monoamine oxidase inhibitor (MAOI) Heart problems, including a previous heart attack or you or any of your family members having QT prolongation Bipolar disorder Liver problems Kidney problems Other serious medical conditions Are pregnant or plan to become pregnant Are breastfeeding It is important that you attend all appointments so your medical provider can regularly follow up on your treatment