Studies involving acoustic and chemical insults show that growth factors represent a compelling class of otoprotective compounds (Yagi et al., The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., In this study, we demonstrate that Dihexa protects lateral line hair cells from aminoglycoside ototoxicity
The authors drew conclusions indicating that Epitalon influences AChE, BuChE, and APP metabolism, positioning it as a possible candidate for the treatment of cholinergic deficiency diseases and cognitive disorders associated with amyloid metabolism [45]
Beyond peripheral nerve, several rodent CNS-injury studies predominantly from the Zagreb pharmacology group that first characterized BPC-157 report benefit
Incorrect injection can cause pain, bruising, or swelling
