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Furthermore, some scientific studies suggest that GLP-1 receptor agonists also signal the liver to stop producing and releasing glucose independently of insulin and glucagon

So post-GLP-1, your knees may no longer be overloaded by mass, but theyre still: Tracking according to old alignment (valgus/varus habits, rotational patterns) Responding to trunk and pelvis strategies that were built around a forward-shifted center of gravity Low back & spinal curves Multiple studies now connect abdominal obesity with: Increased lumbar lordosis and altered spinal alignment Greater gravitational torque on the lumbar spine Higher likelihood of low-back pain independent of age and activity level