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Autologous fibroblast transplantation can decrease disc degeneration and maintain the intervertebral space in cynomolgus monkeys Having established the therapeutic benefits of fibroblast therapy in the small animal rat model, we wanted to see if we could induce the same effects in a large animal model with upright posture

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In the physiological context, our convergent data from intra-OB Ex9, IPGTT and ex vivo OB GLP-1 release experiments indicate local production of GLP-1 in the OB, presumably independently of peripherally derived GLP-1