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Looking ahead to future therapies This is the first drug of its kind to show real biological impact in MASH, Loomba said

Medical Context: Supporting individuals with poor appetite due to stress, illness, or muscle-wasting conditions ( cachexia )

One possible mechanism might be that the modifications of gut microbiota might influence the expression of gut G-protein coupled receptors (Rousseaux et al., 2007), beside manipulating host feeding behavior through hormonal and neural mechanisms (Alcock et al., 2015) have proposed that disruption of oral microbiota could result in chemotherapy-induced inflammation through toll-like receptors (TLRs) and nucleotide oligomerization domain (NOD)-like receptors (NLRs)

One thing worth noting