In light of this, the pathophysiological relevance of the ASPL-VCP interaction warrants further investigation in more physiologically relevant systems, such as patient-derived neurons, animal models, or chronic stress paradigms, which may better recapitulate the characteristic pathological accumulations of ubiquitin and SQSTM1 observed in MSP and related disorders
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FDA experts repeatedly stressed that adding the peptides to the section 503A bulk drug substances list would be a dangerous experiment, with physicians flying blind as far as dosing data and best prescription practices
