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GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)
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A very recent study demonstrated that novel biguanide derivative, IM176, induces prostate cancer cell death in vitro by modulating the AMPK-mTOR and androgen receptor signaling pathways (Kim et al., 2023)
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