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Identification and selection of reproducible and translational biomarkers from omics datasets is a challenging problem for many reasons including small sample size, lack of quality control in sample collection and processing and failure to provide analytical verification of the biomarker, all of which have been addressed in other reviews (Broadhurst and Kell 2006

Effects on mitochondria: Humanin directly improves mitochondrial biogenesis and function [25], while MOTS-c acts via cytosolic and nuclear signalling [1]

Furthermore, it has been observed to counteract various forms of systemic damage and conditions, including tumor cachexia and the adverse effects of certain medical agents

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