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GSH/GSSG levels were measured and LPS-stimulated ROS production was quantified by electron paramagnetic resonance (EPR)

Moreover, probiotics could reduce the intestinal permeability and leaky gut (131), hence reduce the secretion of harmful factors such as LPS, TNF- and RANKL, ultimately ameliorate bone loss and OP development (129, 132, 133) ( Figure 4 )

An additional indicator of synaptic overexcitation is glutamate levels, which are also affected by maternal obesity, with increased concentrations observed in mouse fetuses in the endocannabinoid system within the prefrontal cortex (181)

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