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The Zr released from Mn-MOF downregulated GSH efficiently (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis

10.1176/appi.pn.2013.5b12 Am

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Regarding safety assessment, a prospective study monitored liver function after 3 months of treatment with EGCG combined with vitamin D and D-chiro-inositol, demonstrating favorable surgical outcomes and no hepatotoxicity [189]