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A comparable pattern emerged for depressive symptoms with chronic disease (DCD), where excluding one article (Yaikwawong et al., 2024) reduced heterogeneity from 93% to 78%

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Our findings clearly suggest limiting L-carnitine administration to the most severe VPA-poisoned patients (such as patients with brain edema) and considering alternative therapies that more effectively alter VPA kinetics, such as hemodialysis [8] or meropemen infusion [28]