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At steady state, the amount of drug administered each week equals the amount eliminated, maintaining stable therapeutic concentrations without progressive buildup

Why Fasted Morning Dosing Works Best MOTS-C activates AMP-activated protein kinase (AMPK), a metabolic master switch that: Increases fatty acid oxidation Improves glucose uptake into muscles Enhances mitochondrial biogenesis Mimics some effects of exercise and calorie restriction Taking MOTS-C in a fasted state amplifies AMPK activation because: Lower insulin environment: Fasting keeps insulin low, which allows AMPK to activate more readily

The most common side effects are GI-related (nausea, diarrhea, constipation) and typically resolve by week 12

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