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Ilanne-Parikka P, Eriksson JG, Lindstrm J, Hmlinen H, Keinnen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Rastas M, Salminen V, Aunola S, Sundvall J, Valle T, Lahtela J, Uusitupa M, Tuomilehto J

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The intrinsic agonist model of the ECD for the receptor activation is consistent with the ability of the N-terminally deleted hormone peptides to activate GLP-1R (Figure 9c and d) and the complete independence of GLP-1 and EX4 sequence for activation of the C347K/R mutated receptor (Figure 9e)

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