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The current protocol (CLI 00125 version 8.0) incorporates revisions to improve comprehension and a reduction in the total number of transfused subjects from 600 to 292 subjects following a blinded interim analysis that confirmed the overall incidence of the primary endpoint and the power of the study
Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-alpha induced endothelium dysfunction
Its challenge is that combining two satiety/gastric-emptying pathways may still create tolerability limits
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