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doi: 10.1016/j.bjorl.2017.08.012 74 GraceffaGPatroneRVieniSCampanellaSCalamiaSLaiseIet al

While this is more of a theoretical concern with robust peptides like BPC-157, it's a principle of good laboratory practice

Thereby, ketamine as the model of schizophrenia in rats [193] (as acute ketamine administration was associated with schizophrenia-like or psychotomimetic symptoms with large effect sizes and an increase in positive and negative symptoms [195,196]) might escape from the extraordinary complexity of extrapolation from animal models of mental disorders in general [197,198,199]

The advantage of these types of studies is two-fold