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Funding This article was supported by Novo Nordisk, who was provided with the opportunity to perform a medical accuracy review

The safety profile of oral semaglutide remains consistent with the expected effects of the GLP-1 receptor agonist class, even when used with PPIs like omeprazole

The sublingual formulation enhances the medications effectiveness by allowing for swift absorption into the bloodstream, resulting in faster impacts on appetite regulation and reducing gastrointestinal side effects commonly associated with oral GLP-1 agonists

Rodent studies showed dose-dependent C-cell tumor formation, and while causality in humans is unproven, the risk-benefit ratio makes these absolute contraindications