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Precautions and considerations include: Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (requires careful risk assessment) [1] Severe gastrointestinal disease Pregnancy or breastfeeding (use is not recommended

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There is no literature on whether GSH or GSHee can alter the bias of fentanyl-induced signaling but molecular studies that look at the effects of GSH and GSHee on the interaction between ligand-occupied opioid receptors and coupling of Gproteins and b-arrestins for example, would seem to be feasible 119,120

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