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The 48-hour spacing rule is the only hard constraint

For chronic conditions such as gut healing or general tissue repair, once-daily dosing is often sufficient

liraglutide: Head-to-head study reveals a diabetes risk difference Semaglutide outperforms other GLP-1 drugs for weight loss in psychiatric populations Data collected was weight using calibrated scales, laboratory results for fasting blood glucose [FBG], lipid panel, glycosylated hemoglobin [HbA1c], blood pressure [BP] readings, and liver function tests [LFTs]

They believe semaglutide may help by reducing chronic inflammation and unhealthy fat around organs, both of which are associated with aging